Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : M435-1279
CAS No.: 1359431-16-5
Catalog No.: PC-22046Not For Human Use, Lab Use Only.
M435-1279 is a small molecule inhibitor of UBE2T inhibitor with binding KD of 50.5 uM in MST assay, inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
M435-1279 is a small molecule inhibitor of UBE2T inhibitor with binding KD of 50.5 uM in MST assay, inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.
M435-1279 significantly inhibits the growth of HGC27, AGS, and MKN45 cells.
M435-1279 blocks β-catenin translocation into nuclear and gastric cancer (GC) progression.
M435-1279 blocks UBE2T-RACK1 axis-induced hyperactivation of the Wnt/β-catenin signaling pathway.
| M.Wt | 419.47 | |
| Formula | C18H17N3O5S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-hydroxy-2-oxo-N-(4-sulfamoylphenyl)-1,2,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-b]pyridine-3-carboxamide |
|
1. Yu Z, et al. Oncogene. 2021 Feb;40(5):1027-1042.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
