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Cat. No. Product Name CAS No. Information
PC-60017

DI-591

N/A

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells.

PC-35686

NSC697923

343351-67-7 NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A; NSC697923 impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells, inhibits NF-κB activation induced by PMA, but not by TNFα; specifically inhibits Ubc13-mediated polyubiquitin chain synthesis in vitro, does not inhibits UbcH5c-mediated polyubiquitin chain formation; inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells.
PC-35287

C25-140

1358099-18-9 C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions.
PC-35105

GSK145A

1609945-27-8 GSK145A is a small molecule inhibitor of SUMO-conjugating enzyme E2 with IC50 of 12.5 uM, GSK145A is competitive with the sumoylation of the TRPS1 peptide substrates.
PC-63291

UBE2M-DCN1 inhibitor 52

2089293-14-9 UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM; binds to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line, inhibits DCN1 but not DCN3 stimulated NEDD8 transfer from UBE2F to the cullins.
PC-63182

DI-404

DI-404 is a highly potent, peptidomimetic inhibitor of DCN1-UBC12 protein-protein interaction that bind to DCN1 protein with Kd of 6.9 nM, selectively inhibits the neddylation of cullin 3 over other cullin members; effectively enhances the thermal stability of cellular DCN1 protein at 0.3 uM in H2170 cells, decreases the association of cellular DCN1 protein with cellular UBC12 protein in a dose-dependent manner; effectively increases the level of NRF2 protein, a substrate of cullin 3 CRL (CRL3), but has no effect on CDT1, a substrate of cullin 4A CRL (CRL4A).
PC-61932

NAcM-COV

2089293-81-0 NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays; shows highly selectivity with respect to other protein acetyl-amide-binding sites; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

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