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Chemical Structure : M4K2009
Catalog No.: PC-22015Not For Human Use, Lab Use Only.
M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).
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M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).
M4K2209 shows cell IC50 of 26 nM in NanoBRET target engagement assay.
M4K2209 is equipotent against both wild-type (WT) and mutant ALK2 (G328V, R206H, and R258G) in the biochemical kinase assay.
M4K2009 is also moderately active against the hERG potassium channel (IC50= 8 uM).
| M.Wt | 419.53 | |
| Formula | C25H29N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ensan D, et al. J Med Chem. 2020 May 14;63(9):4978-4996.
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