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MAI-400

Chemical Structure : MAI-400

CAS No.:

MAI-400 (MAI400;MAI 400)

Catalog No.: PC-35569Not For Human Use, Lab Use Only.

MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM; effectively blocks the APC-Asef interaction in cell lysates in a dose-dependent manner, decreases the association of cellular APC protein with cellular Asef in a dose-dependent manner.

Physicochemical Properties

M.Wt 900.94
Formula C41H56N8O15
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4S,7S,10S,13S,16S)-16-(2-((S)-2-(((benzyloxy)carbonyl)amino)propanamido)acetamido)-4-carbamoyl-7-(4-hydroxybenzyl)-13-(hydroxymethyl)-10-isobutyl-6,9,12,15-tetraoxo-5,8,11,14-tetraazanonadecanedioic acid

References

1. Yang X, et al. J Med Chem. 2018 Aug 10. doi: 10.1021/acs.jmedchem.8b01112.

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