Chemical Structure : MASTL inhibitor MKI-2
CAS No.:
438204-56-9
MASTL inhibitor MKI-2
(MASTL kinase inhibitor-2)
Catalog No.: PC-25466Not For Human Use, Lab Use Only.
MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively.
MKI-2 inhibits MASTL kinase rather than other AGC kinases, such as ROCK1, AKT1, PKACα, and p70S6K.
MKI-2 induces mitotic catastrophe of breast cancer cells via MASTL-PP2A regulation.
MKI-2 inhibits the oncogenic properties and enhances the radiosensitivity of breast cancer cells.
MKI-2 shows phenocopies with MASTL-null oocyte in mouse oocytes.
Physicochemical Properties
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M.Wt
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381.44
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Formula
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C22H19N7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-((4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)amino)phenyl)acetonitrile
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References
1. Kang M, et al. Pharmaceuticals (Basel). 2021 Jul 5;14(7):647.
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