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Chemical Structure : MAT2A inhibitor 28
CAS No.: 2439271-82-4
Catalog No.: PC-72337Not For Human Use, Lab Use Only.
MAT2A inhibitor 28 (AZ-28) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 22 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 100 mg | Get quote |
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MAT2A inhibitor 28 (AZ-28) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 22 nM.
MAT2A inhibitor 28 showed inhibition of PRMT5-mediated symmetric dimethylation of arginine (SDMA) with IC50 of 25 nM, inhibited proliferation of HCT116 MTAP knockout cells with an IC50 of 250 nM.
MAT2A inhibitor 28 is a promising in vivo tool that exhibited reduction in tumor SAM levels and antitumor response in an MTAP knockout HCT116 xenograft model.
| M.Wt | 299.758 | |
| Formula | C16H14ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2(1H)-Quinazolinone, 7-chloro-4-(dimethylamino)-1-phenyl- |
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1. Claudia De Fusco, et al. J Med Chem. 2021 May 27;64(10):6814-6826.
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