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MBA-h1

Chemical Structure : MBA-h1

CAS No.: 899759-16-1

MBA-h1

Catalog No.: PC-24409Not For Human Use, Lab Use Only.

MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells.
MBA-h1 inhibitsnecroptosis in MLKL−/− HT-29 cells re-expressing hMLKL1.

Physicochemical Properties

M.Wt 423.52
Formula C26H25N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)phenyl)-2-naphthamide

References

1. Ros U, et al. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.

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