Chemical Structure : MBA-h1
CAS No.: 899759-16-1
Catalog No.: PC-24409Not For Human Use, Lab Use Only.
MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells.
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MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells.
MBA-h1 inhibitsnecroptosis in MLKL−/− HT-29 cells re-expressing hMLKL1.
M.Wt | 423.52 | |
Formula | C26H25N5O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(3-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)phenyl)-2-naphthamide |
1. Ros U, et al. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.
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