Chemical Structure : MBA-m1
CAS No.:
305866-70-0
MBA-m1
Catalog No.: PC-24408Not For Human Use, Lab Use Only.
MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.
MBA-m1 is as effective as Nec1s in mouse cells, acts by disrupting the Hc/groove interaction.
MBA-m1 inhibits necroptosis in Mlkl−/− NIH-3T3 cells re-expressing mMLKL2, does not affect RIPK3:MLKL interaction.
MBA-m1 ameliorates disease in mouse models of MLKL-driven dermatitis and abdominal aortic aneurysm.
MBA-m1 harbored significantly lower counts of CD68+ macrophages and Ly6G+ myeloid cells compared with those treated with vehicle in mice.
Physicochemical Properties
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M.Wt
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440.93
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Formula
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C27H21ClN2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-6-methoxy-2-methylquinolin-4-amine
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References
1. Ros U, et al. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.
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