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Chemical Structure : MBD2 inhibitor APC
Catalog No.: PC-72568Not For Human Use, Lab Use Only.
MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET).
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MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET).
APC suppresses the migration of breast adenocarcinoma MDA-MB-231 (LM1) and colorectal carcinoma HCT116 cells.
APC induces mesenchymal-epithelial transition (MET) on treatment of mesenchymal type of cancer cells.
APC exhibits a potent inhibition of the cancer metastasis to lung in xenograft mice transplanted with the LM1 cells, with no significant effects on body weight.
| M.Wt | 243.307 | |
| Formula | C11H21N3O3 | |
| Appearance | Solid | |
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1. Min Young Kim, et al. Sci Adv. 2019 Nov 20;5(11):eaav9810.
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