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Chemical Structure : MCU-i11
Catalog No.: PC-73143Not For Human Use, Lab Use Only.
MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
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MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i11 directly binds a specific cleft in MICU1 (Kd=2.9 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i11 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.
| M.Wt | 532.615 | |
| Formula | C28H28N4O5S | |
| Appearance | Solid | |
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1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.
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