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Chemical Structure : ME-143
Catalog No.: PC-20714Not For Human Use, Lab Use Only.
ME-143 (NV-143) is a second-generation tumor-specific NADH oxidase inhibitor, binds to purified recombinant ENOX2 with Kd value of 43 nM, shows broad activity against human cancers in vitro and in vivo.
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ME-143 (NV-143) is a second-generation tumor-specific NADH oxidase inhibitor, binds to purified recombinant ENOX2 with Kd value of 43 nM, shows broad activity against human cancers in vitro and in vivo.
ME-143 is a more than 10-fold potent inhibitor of DLD1 proliferation than genistein at 3.125 μM.
ME-143 significantly reduced WNT throughput by 65-75% in both the RKO and DLD1 cell lines.
ME-143 alone and in combination with 5FU and oxaliplatin effectively inhibits the WNT/β-catenin pathway in colorectal cancer cells of diverse genetic background.
| M.Wt | 332.36 | |
| Formula | C21H16O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Morré DJ, et al. Oncol Res. 2014;22(1):1-12.
2. Pintova S, et al. Anticancer Res. 2017 Apr;37(4):1647-1653.
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