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Chemical Structure : MET409
Catalog No.: PC-20979Not For Human Use, Lab Use Only.
MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR).
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MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR).
MET409 displays no cross-reactivity against TGR5, pregnane X receptor, vitamin D receptor or PPAR isoforms (α, γ, δ).
MET409 shows potential for treatment of nonalcoholic fatty liver disease.
| M.Wt | 515.70 | |
| Formula | C32H41N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stefano Fiorucci, et al. Expert Opin Drug Discov. 2021 Oct;16(10):1193-1208.
2. Harrison SA, et al. J Hepatol. 2021 Jul;75(1):25-33.
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