METTL1 inhibitor B22

Chemical Structure : METTL1 inhibitor B22

Catalog No.: PC-28197Not For Human Use, Lab Use Only.

METTL1 inhibitor B22 is a specific small molecule inhibitor of RNA methyltransferase METTL1 with IC50 of 1 uM, selective against a panel of 7 HMTases and the RNA-methyltransferase METTL3/METTL14.

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Biological Activity

METTL1 inhibitor B22 is a specific small molecule inhibitor of RNA methyltransferase METTL1 with IC50 of 1 uM, selective against a panel of 7 HMTases and the RNA-methyltransferase METTL3/METTL14.

Physicochemical Properties

M.Wt	485.50
Formula	C22H27N7O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)(4-(2-hydroxy-4-methoxybenzyl)piperazin-1-yl)methanone

References

1. Bobileva O, et al. ACS Med Chem Lett. 2026 Aug 10;17(9):1941-1947.

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