METTL21A-IN-1

Chemical Structure : METTL21A-IN-1

Catalog No.: PC-27763Not For Human Use, Lab Use Only.

METTL21A-IN-1 (Compound 6d) is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A, highly selective against a panel of 44 human MTases.

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Biological Activity

METTL21A-IN-1 (Compound 6d) is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A, highly selective against a panel of 44 human MTases.
METTL21A is a protein lysine MTase responsible for the trimethylation of HSP70 family members.

Physicochemical Properties

M.Wt	440.34
Formula	C17H15F3N6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxy-N-(3-(trifluoromethoxy)phenyl)tetrahydrofuran-2-carboxamide

References

1. Kocek H, et al. Eur J Med Chem. 2026 Aug 11;319:119227.

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METTL21A-IN-1

Biological Activity

Physicochemical Properties

References

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