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METTL3 inhibitor 54

Chemical Structure : METTL3 inhibitor 54

CAS No.:

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METTL3 inhibitor 54

Catalog No.: PC-21078Not For Human Use, Lab Use Only.

METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.
    METTL3 inhibitor 54 displays no activity against METTL1 and METTL16 up to 200 μM.
    METTL3 inhibitor 54 shows a GI50 of 6 μM for the MOLM-13 AML cell line.

    Physicochemical Properties

    M.Wt 590.82
    Formula C37H46N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((1-isopropyl-2-azaspiro[3.3]heptan-2-yl)methyl)naphthalen-1-yl)amino)methyl)piperidin-3-ol

    References

    1. Bedi RK, et al. ACS Bio Med Chem Au. 2023 Jun 14;3(4):359-370.

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