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MF-094

Chemical Structure : MF-094

CAS No.: 2241025-68-1

MF-094 (MF094)

Catalog No.: PC-35263Not For Human Use, Lab Use Only.

MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM.

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Biological Activity

MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM.
MF-094 increases protein ubiquitination and accelerates mitophagy.

Physicochemical Properties

M.Wt 535.703
Formula C30H37N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-(1-((5-(N-(tert-butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide

References

1. Kluge AF, et al. Bioorg Med Chem Lett. 2018 May 8. pii: S0960-894X(18)30402-5.

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