MFA-1 |CAS:139755-30-9 Probechem Biochemicals

Chemical Structure : MFA-1

MFA-1 (Merck FXR agonist 1)

Catalog No.: PC-63021Not For Human Use, Lab Use Only.

MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA.

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Biological Activity

MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA.
MFA-1 displays an unexpected mode of binding and activation to FXR.

Physicochemical Properties

M.Wt	420.549
Formula	C27H32O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	17beta-(4-hydroxybenzoyl)androsta-3,5-diene-3-carboxylic acid

References

1. Soisson SM, et al. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5337-42.

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MFA-1 (Merck FXR agonist 1)

Biological Activity

Physicochemical Properties

References

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