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Chemical Structure : MG-002
Catalog No.: PC-21688Not For Human Use, Lab Use Only.
MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM.
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MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM.
MG-002 stabilizes eIF4A1-RNA complexes, preferentially inhibits mRNAs with polypurine leader regions, and is a potent inhibitor of translation in vitro and in cellula.
MG-002 exhibits cell viability EC50 of 1-10 nM against TNBC lines (4T1, MDA-MB-231) and ER+/HER2+ breast cancer (BT474), which is more potent anti-neoplastic activity than eFT226.
MG-002 is primarily exerting its cytotoxic effects through eIF4A1/2 engagement.
MG-002 (0.5 mg/kg, oral) more significantly impaired mammary tumor growth compared to eFT226 in 4T1-526 tumors models, inhibited primary TNBC tumor growth through reduced cell proliferation and increased apoptosis.
| M.Wt | 503.51 | |
| Formula | C27H25N3O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cencic R, et al. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2318093121.
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