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MG-132

Chemical Structure : MG-132

CAS No.: 133407-82-6

MG-132 (MG132;MG 132)

Catalog No.: PC-43439Not For Human Use, Lab Use Only.

MG-132 (Z-Leu-leu-leu-al, Zlllal) is a potent, reversible, and cell-permeable proteasome inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.

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Biological Activity

MG-132 (Z-Leu-leu-leu-al, Zlllal) is a potent, reversible, and cell-permeable proteasome inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectivel.
MG-132 induces neurite outgrowth in PC12 cells with optimal concentrations of 20 nM.
MG-132 inhibits autolytic activation of calpain in rabbit erythrocytes at 100 uM; demonstrates in vivo antitumor activity.

Physicochemical Properties

M.Wt 475.62
Formula C26H41N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-

References

1. Tsubuki S, et al. J Biochem. 1996 Mar;119(3):572-6.

2. Tsubuki S, et al. Biochem Biophys Res Commun. 1993 Nov 15;196(3):1195-201.

3. Palombella VJ, et al. Cell. 1994 Sep 9;78(5):773-85.

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