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Chemical Structure : MHPAP
Catalog No.: PC-21368Not For Human Use, Lab Use Only.
MHPAP is a potent cell-permeable anti-cytokine compound, inhibits inflammatory cytokines in monocyte/macrophage-like cells, directly binds to IκB kinase (IKK).
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MHPAP is a potent cell-permeable anti-cytokine compound, inhibits inflammatory cytokines in monocyte/macrophage-like cells, directly binds to IκB kinase (IKK).
MHPAP significantly inhibits IL-6, IL-1beta, IL-8 and TNF-alpha in THP-1 cells.
MHPAP also inhibits NF-κB p65 phosphorylation in the THP-1 cells, without significant effects on c-FOS, ATF-2 and JUN phosphorylations.
MHPAP inhibits the luminescence increased in the LPS-stimulated NF-κB-Luc2 THP-1 cells.
MHPAP inhibit IL-6, IL-1beta, IL-8 and TNF-alpha significantly in LPS-stimulated PBMCs with IC50 of 0.85 and 0.87 µM for IL-6 and IL-1beta respectively.
| M.Wt | 325.36 | |
| Formula | C19H19NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jae B Park. J Pharmacol Exp Ther. 2023 Nov 2:JPET-AR-2023-001830.
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