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MI-1148

Chemical Structure : MI-1148

CAS No.: 1788032-54-1

MI-1148 (MI1148, MI 1148)

Catalog No.: PC-27230Not For Human Use, Lab Use Only.

MI-1148 is a potent, peptidomimetic furin inhibitor with Ki of 5.5 pM, has significant protective effect against anthrax and diphtheria toxin, shows potent anti-infectious activity against H5N1 and H7N1 avian influenza viruses, West Nile and Dengue virus.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MI-1148 is a potent, peptidomimetic furin inhibitor with Ki of 5.5 pM, has significant protective effect against anthrax and diphtheria toxin, shows potent anti-infectious activity against H5N1 and H7N1 avian influenza viruses, West Nile and Dengue virus.

Physicochemical Properties

M.Wt 763.95
Formula C36H57N15O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-N-(4-carbamimidoylbenzyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-(4-(guanidinomethyl)phenyl)acetamido)pentanamido)-3,3-dimethylbutanamido)pentanamide

References

1. Kornelia Hardes, et al. ChemMedChem. 2015 Jul;10(7):1218-31.

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