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Chemical Structure : MI-2-2 hydrochloride
Catalog No.: PC-62484Not For Human Use, Lab Use Only.
MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
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MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM); inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2; suppresses growth of MLL-AF9–transformed BMCs; causes MV4:11 cells growth inhibition of with GI50 of 3 uM.
| M.Wt | 451.955 | |
| Formula | C17H21ClF3N5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. Shi A, et al. Blood. 2012 Nov 29;120(23):4461-9.
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