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MK-0591

Chemical Structure : MK-0591

CAS No.: 136668-42-3

MK-0591 (Quiflapon;MK-591 free base;L-686708)

Catalog No.: PC-42116Not For Human Use, Lab Use Only.

Quiflapon (MK-0591) is a potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay.

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Biological Activity

Quiflapon (MK-0591) is a potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay.
Quiflapon (MK-0591) has no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs.
Quiflapon (MK-0591) potently inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1 and 6.1 nM, respectively.
Quiflapon (MK-0591) inhibits excretion of LTE4 in antigen-challenged allergic animal models.

Physicochemical Properties

M.Wt 587.1713
Formula C34H35ClN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(2-quinolinylmethoxy)-

References

1. Diamant Z, et al. J Allergy Clin Immunol. 1995 Jan;95(1 Pt 1):42-51.

2. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807.

3. Ménard L, et al. Can J Physiol Pharmacol. 1992 Jun;70(6):808-13.

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