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Chemical Structure : MK-0731
Catalog No.: PC-62338Not For Human Use, Lab Use Only.
MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.
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MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM; dispalys >20,000-fold selectivity for KSP over a panel of eight related kinesins (CENP-E, MKLP-1, Kif3A, Kif1B, uKHC, nKHC, KIF14, and MCAK); induces a mitotic block with an IC50 of 19 nM in cells that are refractory to paclitaxel due to P-gp overexpression; induces dose-dependent mitotic arrest in tumors and inhibits tumor growth in mouse xenograft.
Solid Tumors
Discontinued
| M.Wt | 459.513 | |
| Formula | C25H28F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cox CD, et al. J Med Chem. 2008 Jul 24;51(14):4239-52.
2. Cox CD, et al. Anticancer Agents Med Chem. 2010 Nov 1;10(9):697-712.
3. Holen K, et al. Invest New Drugs. 2012 Jun;30(3):1088-95.
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