Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MK-0812 succinate
CAS No.: 851916-42-2
Catalog No.: PC-45834Not For Human Use, Lab Use Only.
A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $224 | In stock | |
| 50 mg | $784 | In stock | |
| 100 mg | $1240 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent CCR2 specific antagonist that blocks MCP-1 mediated response with an IC50 of 3.2 nM; inhibits 125I-MCP-1 binding on isolated monocytes with IC50 of 4.5 nM; reduces macrophage accumulation in adipose tissue in ob/ob mice.
Multiple Sclerosis
Phase 2 Discontinued
| M.Wt | 587.6283 | |
| Formula | C28H40F3N3O7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-, butanedioate (1:1) |
|
1. Wisniewski T, et al. J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
2. O'Brien PD, et al. Diabetes Obes Metab. 2017 Mar 23. doi: 10.1111/dom.12950.
3. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
