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Chemical Structure : MK-1064
CAS No.: 1207253-08-4
Catalog No.: PC-45747Not For Human Use, Lab Use Only.
MK-1064 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki/IC50 of 0.5/18 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MK-1064 is a potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki/IC50 of 0.5/18 nM.
MK-1064 displays >100-fold selectivity over OX1R.
MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats and dogs without inducing cataplexy; also decreases ACTH levels in rats.
| M.Wt | 461.9003 | |
| Formula | C24H20ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[2,2':5',3''-Terpyridine]-3'-carboxamide, 5''-chloro-N-[(5,6-dimethoxy-2-pyridinyl)methyl]- |
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1. Roecker AJ, et al. ChemMedChem. 2014 Feb;9(2):311-22.
2. Gotter AL, et al. Sci Rep. 2016 Jun 3;6:27147.
3. Grafe LA, et al. Neuroscience. 2017 Apr 21;348:313-323.
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