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Chemical Structure : MK-4618
Catalog No.: PC-60734Not For Human Use, Lab Use Only.
MK-4618 (Vibegron, KRP-114V, RVT-901) is a potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM.
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MK-4618 (Vibegron, KRP-114V, RVT-901) is a potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM.
MK-4618 (Vibegron) displays no activity for β1 and β2 receptors (EC50>20 uM).
MK-4618 (Vibegron) dose-dependently increases bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys, dose-dependently increases the circulating glycerol and fatty acid levels in rhesus and rat in vivo.
MK-4618 (Vibegron) shows the potential for treatment of overactive bladder with M2/M3 antimuscarinics.
| M.Wt | 444.535 | |
| Formula | C26H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Edmondson SD, et al. J Med Chem. 2016 Jan 28;59(2):609-23.
2. Di Salvo J, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):346-355.
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