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MK-7288

Chemical Structure : MK-7288

CAS No.: 936626-07-2

MK-7288 (MK7288;MK 7288)

Catalog No.: PC-61337Not For Human Use, Lab Use Only.

A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel histamine H3 receptor inverse agonist for the treatment of sleep apnoea syndrome; significantly prolongs MWT sleep latency, and improves car driving simulation standard deviation of lane position in clinical trials.

Sleep Disorder

Phase 1 Clinical

Physicochemical Properties

M.Wt 401.507
Formula C22H31N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1r,4r)-2'-methoxy-N-methyl-7'-oxo-N-(2-(piperidin-1-yl)ethyl)-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide

References

1. Sun H, et al. J Clin Pharmacol. 2013 Dec;53(12):1294-302.

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