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Chemical Structure : MK-8325 dihydrochloride
Catalog No.: PC-63304Not For Human Use, Lab Use Only.
MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively.
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MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively; also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM); demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells.
HCV Infection
Phase 1 Clinical
| M.Wt | 915.937 | |
| Formula | C43H54Cl2F2N8O6Si | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7.
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