MK-8666 |CAS:1544739-76-5 Probechem Biochemicals

Chemical Structure : MK-8666

Catalog No.: PC-38228Not For Human Use, Lab Use Only.

MK-8666 is a potent, selective partial GPR40 agonist with EC50 of 0.9 nM, shows potential for the treatment of type 2 diabetes mellitus.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MK-8666 is a potent, selective partial GPR40 agonist with EC50 of 0.9 nM, shows potential for the treatment of type 2 diabetes mellitus.

M.Wt	521.628
Formula	C29H31NO6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(6R)-3-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

1. Lu J, et al. Nat Struct Mol Biol. 2017 Jul;24(7):570-577.

2. Krug AW, et al. Clin Transl Sci. 2017 Sep;10(5):404-411.