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Chemical Structure : MK-8719
CAS No.: 1382799-40-7
Catalog No.: PC-72110Not For Human Use, Lab Use Only.
MK-8719 (MK8719) is a a highly potent, selective, CNS-penetrable inhibitor of O-GlcNAcase (OGA) with Ki of 7.9 nM (hOGA).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $958 | In stock | |
| 100 mg | $1680 | In stock | |
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MK-8719 (MK8719) is a a highly potent, selective, CNS-penetrable inhibitor of O-GlcNAcase (OGA) with Ki of 7.9 nM (hOGA).
MK-8719 displays no effect against human hexosaminidase A/B (HexA/B) and human N-acetylglucosaminidase (NAGLU), as well as a panel of > 100 receptor and enzyme targets.
MK-8719 inhibits human OGA enzyme with comparable activity against the corresponding enzymes from mouse, rat, and dog.
MK-8719 produces a dose-dependent increase in O-GlcNAc in PC12 cells with IC50 of 52.7 nM.
MK-8719 elevates brain and peripheral blood mononuclear cell O-GlcNAc levels in a dose-dependent manner in vivo, demonstrateed robust target engagement in the brains of rats and rTg4510 mice.
| M.Wt | 268.279 | |
| Formula | C9H14F2N2O3S | |
| Appearance | Solid | |
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1. Wang X, et al. J Pharmacol Exp Ther. 2020 Aug;374(2):252-263.
2. Selnick HG, et al. J Med Chem. 2019 Nov 27;62(22):10062-10097.
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