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Chemical Structure : MK-8876
Catalog No.: PC-60429Not For Human Use, Lab Use Only.
A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively.
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A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively; demonstrates a pan-genotypic potency profile and maintains potency against clinically relevant mutants; has moderate bioavailability in rats and dogs, but shows low plasma clearance characteristics consistent with once-daily dosing.
HCV Infection
Phase 1 Clinical
| M.Wt | 614.62 | |
| Formula | C32H24F2N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McComas CC, et al. ChemMedChem. 2017 Sep 7;12(17):1436-1448.
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