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MK2-IN-1

Chemical Structure : MK2-IN-1

CAS No.: 1314118-92-7

MK2-IN-1 (MK2 Inhibitor)

Catalog No.: PC-43243Not For Human Use, Lab Use Only.

MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2(MK2) inhibitor with IC50 of 0.11 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2 (MK2) inhibitor with IC50 of 0.11 uM.
MK2-IN-1 shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition.
MK2-IN-1 inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion.
MK2-IN-1 also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.

Physicochemical Properties

M.Wt 472.966
Formula C27H25ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-

References

1. Rao AU, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.

2. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.

3. Huang X, et al. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.

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