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MKC-733

Chemical Structure MKC-733

CAS No.: 194093-42-0

MKC-733 (MKC733;Pumosetrag;DDP 733)

Catalog No.: PC-61221Not For Human Use, Lab Use Only.

A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors; dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron, also accelerates gastric emptying in some animal models.

Irritable Bowel Syndrome

Phase 2 Discontinued

Physicochemical Properties

M.Wt 39.838
Formula C15H18ClN3O2S
CAS No. 194093-42-0
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

Thieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI)

Clinical Information

References

1. Coleman NS, et al. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.

2. Fujita T, et al.

3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.

4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.

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