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Chemical Structure : MKI-1
CAS No.: 1190277-80-5
Catalog No.: PC-20555Not For Human Use, Lab Use Only.
MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | $988 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM.
MKI-1 (15 μM, 20h) inhibited the phosphorylation of ENSA in MCF7 and T47D cells, also inhibited the phosphorylation of ENSA in colcemid-induced mitotic MCF7 cells, did not modulate phosphorylated AKT, GSK-3β, and p70S6K.
MKI-1 inhibits various oncogenic properties of MCF7 cells and does not affect the viability of MCF10A cells.
MKI-1 reduces tumor growth and radiosensitivity of breast cancer cells.
MKI-1 reduces c-Myc stability through PP2A activation in MCF7 cells, inhibits meiotic resumption and spindle formation in mouse oocytes.
| M.Wt | 302.34 | |
| Formula | C18H14N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC(N4C=CC=C4)=C3 |
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1. Kim AY, et al. Front Oncol. 2020 Sep 29;10:571601.
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