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Chemical Structure : ML-SI3
Catalog No.: PC-73026Not For Human Use, Lab Use Only.
ML-SI3 (Mucolipin-specific synthetic inhibitor 3) is a synthetic antagonist of transient receptor potential mucolipin 1 (TRPML1), prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.
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ML-SI3 (Mucolipin-specific synthetic inhibitor 3) is a synthetic antagonist of transient receptor potential mucolipin 1 (TRPML1), prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy.
The TRPML1 inhibitor ML-SI3 binds the same cavity as its agonist ML-SA1.
ML-SI3 competes with ML-SA1 to block the channel activity.
ML-SI3 blocks TRPML1 channel activation yet does not inhibit PI(3,5)P2-dependent activation of the channel.
Transient receptor potential mucolipin 1 (TRPML1) regulates lysosomal calcium signaling, lipid trafficking, and autophagy-related processes.
| M.Wt | 429.579 | |
| Formula | C23H31N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Philip Schmiege, et al. Structure. 2021 Nov 4;29(11):1295-1302.e3.
2. Li D, et al. Autophagy. 2021 Apr;17(4):872-887.
3. Leser C, et al. Eur J Med Chem. 2021 Jan 15;210:112966.
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