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Chemical Structure : ML179
Catalog No.: PC-38444Not For Human Use, Lab Use Only.
ML179 (SR-1309, PubChem CID 45100448) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).
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ML179 (SR-1309) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).
ML179 is potent in a variety of breast cancer cell lines in MTT assays.
ML179 significantly reduced mRNA expression of FXR targets ATP binding cassette subfamily C member 2/multidrug resistance associated protein 2 (ABCC2/MRP2), nuclear receptor subfamily 0, groupB, member 2/small heterodimer partner (NR0B2/SHP), and ATP binding cassette subfamily B member 11/bile salt export pump (ABCB11/BSEP) in HepG2 cells and primary mouse hepatocytes.
| M.Wt | 422.44 | |
| Formula | C21H25F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Busby S, et al. National Center for Biotechnology Information (US); 2010-.
2. Swati Ghosh, et al. Hepatology. 2021 Dec;74(6):3284-3300.
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