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Chemical Structure : ML358
Catalog No.: PC-62388Not For Human Use, Lab Use Only.
ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM.
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ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM; shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM); sensitizes the model nematode C. elegans to oxidants and anthelmintics; exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes; a valuable chemical probe to study regulation and function of SKN-1 in vivo.
| M.Wt | 430.794 | |
| Formula | C21H26Cl3NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peddibhotla S, et al. ACS Chem Biol. 2015 Aug 21;10(8):1871-9.
2. Peddibhotla S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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