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Chemical Structure : ML365
CAS No.: 947914-18-3
Catalog No.: PC-42995Not For Human Use, Lab Use Only.
ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM).
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|---|---|---|---|
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| 100 mg | $358 | In stock | |
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ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM).
ML365 displays 98-fold selectivity over TASK1 (KCNK9), >7,500-fold over Kir2.1, KCNQ2 and hERG in thallium influx fluorescent assay.
ML365 is a useful pharmacological probe for in vitro studies of TASK1 function.
| M.Wt | 360.4058 | |
| Formula | C22H20N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]- |
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1. Zou B, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Skarsfeldt MA, et al. Pflugers Arch. 2016 Apr;468(4):643-54.
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