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Chemical Structure : ML418
CAS No.: 1928763-08-9
Catalog No.: PC-60576Not For Human Use, Lab Use Only.
ML418 (ML-418) is the first potent, selective, CNS penetrating inward rectifier potassium channel Kir7.1 (KCNJ13) inhibitor with IC50 of 0.31 uM.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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ML418 (ML-418) is the first potent, selective, CNS penetrating inward rectifier potassium channel Kir7.1 (KCNJ13) inhibitor with IC50 of 0.31 uM.
ML418 displays >17-fold selective over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2, and Kir4.1 except for Kir6.2/SUR1 (equally potent).
ML418 possesses a DMPK profile suitable for both in vitro and in vivo studies aimed at modulating both peripheral and central Kir7.1 potassium channels.
| M.Wt | 377.87 | |
| Formula | C19H24ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
iso-Propyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate |
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1. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23.
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