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Chemical Structure : MM-401
CAS No.: 1442106-10-6
Catalog No.: PC-70114Not For Human Use, Lab Use Only.
MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
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MM-401 is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM.
MM-401 represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM).
MM-401 specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion.
MM-401 reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.
| M.Wt | 586.726 | |
| Formula | C29H46N8O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide |
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1. Cao F, et al. Mol Cell. 2014 Jan 23;53(2):247-61.
2. Zhang H, et al. Cell Stem Cell. 2016 Apr 7;18(4):481-94.
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