Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MM0299 analog 13
Catalog No.: PC-49755Not For Human Use, Lab Use Only.
MM0299 analog 13 (MM 0299 derivative 13) is a potent, selective, orally bioavailable, brain-penetrant inhibitor of lanosterol synthase (LSS, competition EC50=28.7 nM) with anti-proliferative activity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MM0299 analog 13 (MM 0299 derivative 13) is a potent, selective, orally bioavailable, brain-penetrant inhibitor of lanosterol synthase (LSS, competition EC50=28.7 nM) with anti-proliferative activity.
MM0299 analog 13 induced the upregulation of 24(S),25-epoxycholesterol (EPC), and maintained anti-proliferative activity in both Mut6 cells (IC50 = 0.0443 μM) and the human GSC line UTSW63 (IC50 = 0.0293 μM).
MM0299 analog 13 was stable in plasma (>24 h) and displayed superior metabolic stability in comparison with MM0299.
MM0299 analog 13 (20 mg/kg p.o.) induced the production of EPC in orthotopic GBM tumors but not normal mouse brain.
| M.Wt | 468.33 | |
| Formula | C25H19Cl2NO4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Thu P Nguyen, et al. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
