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Chemical Structure : MMRi64
CAS No.: 430458-66-5
Catalog No.: PC-62554Not For Human Use, Lab Use Only.
MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.
MMRi64 potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21.
MMRi64 selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.
| M.Wt | 410.298 | |
| Formula | C22H17Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-[(2,3-Dichlorophenyl)[(4-methyl-2-pyridinyl)amino]methyl]-8-quinolinol |
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1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035.
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