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Chemical Structure : MMRi71
Catalog No.: PC-20688Not For Human Use, Lab Use Only.
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
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MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
MMRi71 exhibits anti-proliferation effect against the wtp53-bearing NALM6 (p53-dependent) and shP53NALM6 (p53-independent) leukemia cell lines with IC50 of 0.23 and 0.29 uM, respectively.
MMRi71 shows strong anti-leukemic activity in the cell proliferation inhibitory assay along with the dose-dependent inhibition of MDM2B E3 ligase activity.
MMRi71 induces MDM2-dependent proteasomal degradation of MDM4 and the lysosome-dependent degradation of FTH1.
MMRi71 effectively kills p53-null leukemia cells, an activity that conventional MDM2-p53 disrupting inhibitors lack.
| M.Wt | 490.94 | |
| Formula | C26H23ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rati Lama, et al. Molecules. 2022 Nov 8;27(22):7665.
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