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Chemical Structure : MO-I-1100
Catalog No.: PC-49471Not For Human Use, Lab Use Only.
MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.
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MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells.
MO-I-1100 (1 uM) inhibited cell viability of FOCUS cells, which have high level ASPH expression, but had no effect on NIH3T3 cells which lacked ASPH on the cell surface.
MO-I-1100 reduced cell motility and invasiveness in human and murine HCC cell lines, MO-I-1100 (5 uM) reduced expression of Notch responsive genes (HES1 and HEY1).
MO-I-1100 (50 mg/kg) reduces tumor growth in an intrahepatic orthotopic xenograft model of HCC, with significantly reduced levels of activated Notch 1, HES1 and HEY1.
| M.Wt | 379.811 | |
| Formula | C17H14ClNO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aihara A, et al. Hepatology. 2014 Oct;60(4):1302-13.
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