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Chemical Structure : MP-HJ-1b
Catalog No.: PC-35617Not For Human Use, Lab Use Only.
MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation.
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MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation; shows activities against a panel of more than 1000 human cancer cell lines with a wide variety of tissue origins, also induces the spike-like conformation of microtubules in vitro and in vivo, which is different from typical microtubule modulators; exhibits an interesting property of general cytotoxicity instead of Ras-mutant-specific killing (A549 KRAS-G12S, IC50=0.04 uM); MPHJ-1b displayed favorable pharmacological properties for overcoming tumor MDR both in vitro and in vivo.
| M.Wt | 373.43 | |
| Formula | C21H15N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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