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Chemical Structure : MPK-09
Catalog No.: PC-60182Not For Human Use, Lab Use Only.
A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.
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MPK-09 is a highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator.
MPK-09 exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells.
MPK-09 enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis.
| M.Wt | 418.53 | |
| Formula | C24H34O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Metri PK, et al. ACS Chem Biol. 2013 Jul 19;8(7):1429-34.
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