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Chemical Structure : MPO inhibitor IN-4
Catalog No.: PC-49685Not For Human Use, Lab Use Only.
MPO inhibitor IN-4 is a highly potent, selective, irreversible and orally bioavailable myeloperoxidase (MPO) inhibitor.
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MPO inhibitor IN-4 is a highly potent, selective, irreversible and orally bioavailable myeloperoxidase (MPO) inhibitor.
IN-4 is selective for extracellular MPO over intracellular (neutrophil) MPO, displays significant selectivity over the closely related thyroid peroxidase (TPO).
IN-4 displays similar in vitro potency across peroxidation, plasma and NETosis assays (IC50=80-177 nM).
IN-4 shows good exposure, low clearance and high oral bioavailability in mice, rats and dogs.
IN-4 (25-250 mg/kg/day, oral) exhibited a dose-dependent inhibition of MPO activity in three mouse models of inflammation.
| M.Wt | 359.47 | |
| Formula | C23H25N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Regard JB, et al. Biochem Pharmacol. 2023 Jan 21:115418. doi: 10.1016/j.bcp.2023.115418.
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