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Chemical Structure : MPT0B002
Catalog No.: PC-60553Not For Human Use, Lab Use Only.
MPT0B002 is a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.
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MPT0B002 is a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells.
MPT0B002 disrupts tubulin polymerization and arrests cell cycle at the G2/M phase.
MPT0B002 induces apoptosis associated with increased levels of cleaved caspase-3 and cleaved PARP.
| M.Wt | 325.36 | |
| Formula | C19H19NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yeh YY, et al. Invest New Drugs. 2017 Aug;35(4):427-435.
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