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Chemical Structure : MPT0B098
Catalog No.: PC-60910Not For Human Use, Lab Use Only.
A potent microtubule inhibitor that not only inhibits the expression levels of HIF-1α protein but also destabilizes HIF-1α mRNA.
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A potent microtubule inhibitor that not only inhibits the expression levels of HIF-1α protein but also destabilizes HIF-1α mRNA; binds to the colchicine-binding site of tubulin, inhibits growth of various human cancer cells, including chemoresistant cells with IC50 70-150 nM; exhibit less inhibitory effect against human umbilical vein endothelial cells (HUVEC) with IC50 of 510 nM, arrests cells in the G2-M phase and induces cell apoptosis; effectively suppresses tumor growth and microvessel density of tumor specimens in vivo.
| M.Wt | 366.43 | |
| Formula | C20H18N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheng YC, et al. Mol Cancer Ther. 2013 Jul;12(7):1202-12.
2. Peng HY, et al. PLoS One. 2016 Jul 1;11(7):e0158440.
3. Chang JY, et al. Medchemcomm. 2010;1(2):152-5.
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